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Name: Yoshio Fukui
Title:
Associate
Professor
Research
area: Actomyosin System in Dictyostelium discoideum
Degree:
Ph.D.
Voice:
312.503.4234
Fax:
312.503.7912
e-mail:
y-fukui@northwestern.edu
Link
to lab webpage: Yoshio Fukui Home
Page is under construction. Temporay Link to: http://faculty-web.at.northwestern.edu/med/fukui/01-FukuiFacWeb.html
Detailed research description:
My long-term research interest is to understand the structure and function of
the cytoskeletal system in cell movement and cell
division. More specifically my research focuses on the mechanism of force
generation and dynamic reorganization of the actomyosin
system in a cellular slime mold, Dictyostelium discoideum. Experimental protocols include purifying actin, myosin, and related proteins; labeling them with a
fluorescence probe; and micro-injecting them into living cells. We analyze
the dynamics of the labeled protein with digital image processor using
high-resolution video and digital fluorescence microscopies.
Representative publications:
Fukui, Y., S. Engler,
S. Inoué, and E. L. De Hostos
(1999). Architectural dynamics and gene replacement
of coronin suggest its role in cytokinesis. Cell Motil.
Cytoskel. 42, 204-217.
Fukui,
Y., T. K.-Yumura, and S. Yumura
(1999). Myosin
II-independent F-actin flow contributes to
cell locomotion
in Dictyostelium. J. Cell Sci. 112, 877-886.
Fukui,
Y., E. L. de Hostos, S. Yumura,
T. K.-Yumura, and
S. Inoué (1999). Architectural dynamics of eupodia
suggest their role for invasive locomotion in
Dictyostelium. Exp. Cell Res. 249,
33-45.
Fukui,
Y., T. Q. P. Uyeda, C. Kitayama,
and S. Inoué
(1999). Migration forces in Dictyostelium
measured by
centrifuge DIC microscopy. Biol. Bull. 197, 260-262.
Fukui,
Y.(2000).
High-resolution real-time video microscopy
suggests two-step cytokinetic mechanism in
Dictyostelium. Microscop.
Res. Tech. (in press).
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