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Name: Yoshio Fukui
Title:
Associate
Professor
Research
area: Actomyosin
System in Dictyostelium discoideum
Degree:
Ph.D.
Voice:
312.503.4234
Fax:
312.503.7912
e-mail:
y-fukui@northwestern.edu
Link
to lab webpage: : http://faculty-web.at.northwestern.edu/med/fukui/01-FukuiFacWeb.html
Detailed research
description:
My long-term research interest is to understand the structure and function of
the cytoskeletal system in cell movement and cell division. More specifically
my research focuses on the mechanism of force generation and dynamic
reorganization of the actomyosin system in a cellular slime mold,
Dictyostelium discoideum. Experimental protocols include purifying actin,
myosin, and related proteins; labeling them with a fluorescence probe; and
micro-injecting them into living cells. We analyze the dynamics of the
labeled protein with digital image processor using high-resolution video and
digital fluorescence microscopies.
Representative publications:
Fukui, Y., S. Engler, S. Inoué, and E. L.
De Hostos
(1999). Architectural dynamics and gene replacement
of coronin suggest its role in cytokinesis. Cell Motil.
Cytoskel. 42, 204-217.
Fukui,
Y., T. K.-Yumura, and S. Yumura (1999). Myosin
II-independent F-actin flow contributes to cell locomotion
in Dictyostelium. J. Cell Sci. 112, 877-886.
Fukui,
Y., E. L. de Hostos, S. Yumura, T. K.-Yumura, and
S. Inoué (1999). Architectural dynamics of eupodia
suggest their role for invasive locomotion in
Dictyostelium. Exp. Cell Res. 249, 33-45.
Fukui,
Y., T. Q. P. Uyeda, C. Kitayama, and S. Inoué
(1999). Migration forces in Dictyostelium measured by
centrifuge DIC microscopy. Biol. Bull. 197, 260-262.
Fukui,
Y.(2000). High-resolution real-time video microscopy
suggests two-step cytokinetic mechanism in
Dictyostelium. Microscop. Res. Tech. (in press).
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